In vitro effect of redox signaling molecules onregulating Nrf2 pathway

Summary of studies conducted by:
University of Bath, UK
Western Sydney University, Australia
Key findings
Internationally renowned universities have researched the impact of redox signaling molecules on different types of cells.

  • The research conducted independently by both universities found that the Nrf2 pathway was significantly impacted by redox
    signaling molecules.
  • Nrf2 is a genetic pathway that plays a vital role in regulating genes that support response and resilience to a range of stressors.
    These stressors may include fatigue, emotional stress, inflammation, environmental pollution, and even lifestyle factors such as
    poor diet or sedentary behavior.
  • One key finding in the research was that supplementation with redox signaling molecules increased Nrf2 activity by up to 60%.
    This is significant given the Nrf2 pathway enhances the antioxidant protective system inside our bodies’ cells. (See fig. 7B.)
  • Another key finding is that supplementation with redox signaling molecules increased cells’ production of protective proteins
    like glutathione, which play important roles in promoting overall balance. The research revealed that supplementation with
    redox signaling molecules increased glutathione production by 40% in healthy cells and that it restored glutathione production
    in compromised cells even more—by 55%. (See figs. 12A and 12B.)

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